The film which also stars Michelle Monaghan Juliette Lewis and Jamie Foxx took �2,345,138 in its first weekend of release.
Josh Berger, President and Managing Director of Warner Bros UK, said: "We are thrilled to be working with Robert Downey Jr, Todd Phillips and Zach Galifianakis again on Due Date.
"With the stellar box office of The Hangover and the No 1 opening this weekend with Due Date, Todd has proved once again that he creates films that audiences love to go and see".
Due Date reunites Phillips with key members of his filmmaking team from The Hangover, including director of photography Lawrence Sher, production designer Bill Brzeski, editor Debra Neil-Fisher, composer Christophe Beck and costume designer Louise Mingenbach.
Downey plays Peter Highman, an expectant first-time father whose wife's due date is a mere five days away.
As Peter hurries to catch a flight home from Atlanta to be at her side, he is forced to hitch a ride with aspiring actor Ethan Tremblay (Galifianakis), on a cross-country road trip that will ultimately destroy several cars, numerous friendships and Peter's last nerve.
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[Source: Coventry Telegraph - The Geek Files]
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